Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1828311 | 0.97 | HSD17B10 (0.52) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| SCHEMBL1828521 | 0.95 | HSD17B10 (0.55) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL8135380 | 0.77 | HSD17B10 (0.80) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL27851138 | 0.77 | HSD17B10 (0.80) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL8119680 | 0.77 | HSD17B10 (0.80) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL27671770 | 0.77 | HSD17B10 (0.80) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL1691353 | 0.77 | HSD17B10 (0.80) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL29151847 | 0.75 | HSD17B10 (0.75) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL229 | 0.73 | HSD17B10 (1.00) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 | |
| Diphenylamine SCHEMBL1619083 | 0.73 | HSD17B10 (1.00) | HSD17B10ALDH1A1TDP1ALOX12L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029551-B1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MSD ITALIA SRL (IT) | 2018-10-31 | — | — | EP | disclosed |
| US-10040749-B2 | Opsin-binding ligands, compositions and methods of use | BIKAM PHARMACEUTICALS INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-20150038574-A1 | Opsin-Binding Ligands, Compositions and Methods of Use | BIKAM PHARMACEUTICALS, INC. (US) | 2015-02-05 | — | — | US | disclosed |
| CN-103420988-A | Pyridinone and pyridazinone derivatives as inhibitors of poly(adp-ribose)polymerase (parp) | ANGELETTI P IST RICHERCHE BIO | 2013-12-04 | — | — | CN | disclosed |
| US-8188084-B2 | Pyridinone and pyridazinone derivatives as inhibitors of poly (ADP-ribose) polymerase (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA. (IT) | 2012-05-29 | — | — | US | disclosed |
| CN-101501006-A | Pyridone and pyridazinone derivatives as poly (ADP-ribose) polymerase (PARP) inhibitors | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-08-05 | — | — | CN | disclosed |
| US-20090176765-A1 | Pyridinone and Pyridazinone Derivatives as Inhibitors of Poly (Adp-Ribose) Polymerase (Parp) | MSD ITALIA S.R.L. (IT) | 2009-07-09 | — | — | US | disclosed |
| EP-2029551-A2 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007138351-A2 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038574-A1 | Opsin-Binding Ligands, Compositions and Methods of Use | CRYAB, CRYAA, PDE6C | HSD17B10 2983/4885ALDH1A1 2346/4885TDP1 2588/4885 |
| US-10040749-B2 | Opsin-binding ligands, compositions and methods of use | CRYAB, CRYAA, PDE6C | HSD17B10 2983/4885ALDH1A1 2346/4885TDP1 2588/4885 |
| US-20090176765-A1 | Pyridinone and Pyridazinone Derivatives as Inhibitors of Poly (Adp-Ribose) Polymerase (Parp) | PARP1, PARP2, PARP3 | HSD17B10 2665/4885ALDH1A1 278/4885TDP1 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.