Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 10/20 | 0.73 |
| ▸ | CACNG8 | Q8WXS5 | 9/20 | 0.73 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.55 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.55 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.55 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.55 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.55 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.55 |
| ▸ | FABP3 | P05413 | 3/20 | 0.46 |
| ▸ | FABP4 | P15090 | 3/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.42 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190698 | 0.85 | GRIA1 (1.00) | GRIA1CACNG8GRIK1GRIK2GRIK3 | |
| SCHEMBL18190555 | 0.84 | GRIA1 (0.66) | GRIA1CACNG8GRIK1GRIK2GRIK3 | |
| SCHEMBL21900278 | 0.83 | GRIA1 (0.73) | GRIA1CACNG8GRIK1GRIK2GRIK3 | |
| SCHEMBL18203027 | 0.81 | GRIA1 (0.79) | GRIA1CACNG8GRIK1GRIK2GRIK3 | |
| SCHEMBL18190663 | 0.81 | GRIA1 (0.52) | GRIA1CACNG8GRIK1GRIK2GRIK3 | |
| SCHEMBL18190610 | 0.79 | GRIA1 (0.75) | GRIA1CACNG8GRIK1GRIK2GRIK3 | |
| SCHEMBL18190537 | 0.78 | GRIA1 (0.79) | GRIA1CACNG8 | |
| SCHEMBL18190398 | 0.78 | GRIA1 (0.79) | GRIA1CACNG8GRIK1GRIK2GRIK3 | |
| SCHEMBL18190602 | 0.78 | GRIA1 (1.00) | GRIA1CACNG8 | |
| SCHEMBL18190411 | 0.77 | GRIA1 (1.00) | GRIA1CACNG8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288936-B1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-06 | — | — | EP | claimed |