Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 7/20 | 0.52 |
| ▸ | CACNG8 | Q8WXS5 | 5/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.45 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190668 | 0.85 | GRIA1 (0.49) | GRIA1CACNG8GRIK1GRIA2GRIA3 | |
| SCHEMBL20838850 | 0.85 | GRIA1 (0.49) | GRIA1CACNG8GRIK1GRIA2GRIA3 | |
| SCHEMBL18190719 | 0.84 | MAPT (0.52) | GRIA1CACNG8KMT2AALDH1A1HPGD | |
| SCHEMBL18190663 | 0.83 | GRIA1 (0.52) | GRIA1CACNG8GRIK1GRIA2GRIA3 | |
| SCHEMBL21900281 | 0.83 | GRIA1 (0.47) | GRIA1CACNG8GRIK1GRIA2GRIA3 | |
| SCHEMBL18190550 | 0.81 | GRIA1 (0.69) | GRIA1CACNG8GRIK1GRIA2GRIA3 | |
| SCHEMBL21900278 | 0.81 | GRIA1 (0.73) | GRIA1CACNG8GRIK1GRIA2GRIA3 | |
| SCHEMBL18190616 | 0.80 | SMYD3 (0.50) | GRIA1CACNG8KMT2APOLBALDH1A1 | |
| SCHEMBL18190596 | 0.79 | TP53 (0.47) | GRIA1CACNG8KMT2APOLBALDH1A1 | |
| SCHEMBL21973786 | 0.78 | GRIA1 (0.56) | GRIA1CACNG8GRIK1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288936-B1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-06 | — | — | EP | claimed |