Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.47 |
| ▸ | CACNG8 | Q8WXS5 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190715 | 0.89 | ROCK2 (0.46) | GRIA1CACNG8KMT2ATERTPOLB | |
| SCHEMBL21900283 | 0.83 | GRIA1 (0.52) | GRIA1CACNG8KMT2AGRIK1GRIA2 | |
| SCHEMBL18190663 | 0.80 | GRIA1 (0.52) | GRIA1CACNG8KMT2AGRIK1GRIA2 | |
| SCHEMBL18190668 | 0.77 | GRIA1 (0.49) | GRIA1CACNG8KMT2AGRIK1GRIA2 | |
| SCHEMBL18190642 | 0.76 | GRIA1 (0.49) | GRIA1CACNG8KMT2AMEN1 | |
| SCHEMBL4632581 | 0.76 | HNF4A (0.58) | KMT2APOLBMEN1KDM4EGAA | |
| SCHEMBL30394743 | 0.76 | HNF4A (0.58) | KMT2APOLBMEN1KDM4EGAA | |
| SCHEMBL30728866 | 0.75 | TUBB4A (0.49) | KMT2APOLBMEN1KDM4EMAPT | |
| SCHEMBL21900278 | 0.75 | GRIA1 (0.73) | GRIA1CACNG8KMT2AGRIK1GRIA2 | |
| SCHEMBL17799595 | 0.74 | HNF4A (0.56) | KMT2APOLBMEN1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288936-B1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-06 | — | — | EP | claimed |