Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2190081 | 1.00 | L3MBTL1 (0.40) | L3MBTL1GRK2CASP6CASP8CTDSP1 | |
| SCHEMBL2190076 | 1.00 | L3MBTL1 (0.40) | L3MBTL1GRK2CASP6CASP8CTDSP1 | |
| SCHEMBL22492141 | 0.87 | AKR1C3 (0.43) | L3MBTL1ALDH1A1CYP2C19TAAR1HPGD | |
| SCHEMBL2187465 | 0.79 | KMT2A (0.43) | ALDH1A1CYP2C9CYP2C19HPGDHTT | |
| SCHEMBL2187458 | 0.79 | KMT2A (0.43) | ALDH1A1CYP2C9CYP2C19HPGDHTT | |
| SCHEMBL22492109 | 0.76 | AKR1C3 (0.46) | L3MBTL1ALDH1A1CYP2C19HTTHDAC4 | |
| SCHEMBL22492107 | 0.76 | AKR1C3 (0.46) | L3MBTL1ALDH1A1CYP2C19HTTHDAC4 | |
| SCHEMBL2189968 | 0.75 | KDM1A (0.47) | CYP2C9CYP2C19TAAR1NPC1KMT2A | |
| SCHEMBL2189960 | 0.75 | KDM1A (0.47) | CYP2C9CYP2C19TAAR1NPC1KMT2A | |
| SCHEMBL2189964 | 0.75 | KDM1A (0.47) | CYP2C9CYP2C19TAAR1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172297-A1 | Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof | PFIZER INC | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172297-A1 | Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof | GRIK5, GABRE, GRIK2 | L3MBTL1 4856/4885GRK2 154/4885CASP6 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.