Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876029 | 0.88 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL21903995 | 0.86 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL509754 | 0.85 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL21902703 | 0.80 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL510782 | 0.78 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL21902092 | 0.77 | KDM4E (0.61) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL16792569 | 0.77 | MEN1 (0.71) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL18181837 | 0.77 | MEN1 (0.46) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL510406 | 0.77 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1KDM4EPOLBHSPB1 | |
| SCHEMBL27300366 | 0.77 | MEN1 (0.47) | ALDH1A1L3MBTL1KDM4EHSPB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11155539-B2 | 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-10-26 | — | — | US | disclosed |
| US-20200123141-A1 | 4-Pyridinylmethyl-Morpholine Derivatives and the use thereof as Medicament | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-04-23 | — | — | US | disclosed |
| WO-2020079042-A1 | 4-PYRIDINYLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155539-B2 | 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 1678/4885L3MBTL1 4788/4885KDM4E 559/4885 |
| US-20200123141-A1 | 4-Pyridinylmethyl-Morpholine Derivatives and the use thereof as Medicament | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 1678/4885L3MBTL1 4788/4885KDM4E 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.