Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | GRB2 | P62993 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | RECQL | P46063 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | CASP1 | P29466 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | CASP7 | P55210 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.71 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dactinomycin SCHEMBL20771836 | 0.92 | SMN1; SMN2 (0.60) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL3844 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL26186613 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL27304406 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL3845 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL19770615 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL6152 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL13659669 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL6939686 | 0.84 | GRB2 (1.00) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 | |
| Dactinomycin SCHEMBL28168861 | 0.84 | GRB2 (0.99) | SMN1; SMN2GRB2MAPTRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329729-B2 | Quinuclidine derivatives as muscarinic M3 receptor antagonists | ASTRAZENECA AB (SE) | 2012-12-11 | — | — | US | disclosed |
| US-20110172237-A1 | QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS | ASTRAZENECA UK LIMITED (GB) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172237-A1 | QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS | CHRM3, CHRM2, CHRM1 | SMN1; SMN2 4555/4885GRB2 3825/4885MAPT 2746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.