Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30942773 | 0.89 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL21997212 | 0.89 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1CCR5ENPP2MAPT | |
| SCHEMBL27193533 | 0.86 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL22001681 | 0.84 | SIGMAR1 (0.45) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL21904679 | 0.84 | SIGMAR1 (0.45) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL30865762 | 0.83 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL22001668 | 0.83 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL4803972 | 0.82 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL4805754 | 0.82 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 | |
| SCHEMBL4803965 | 0.82 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1MAPK1L3MBTL1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10744136-B2 | Sulfonamide derivatives as JAK inhibitors | AVISTA PHARMA SOLUTIONS, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-10744136-B2 | Sulfonamide derivatives as JAK inhibitors | AVISTA PHARMA SOLUTIONS, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20200138811-A1 | Chemical Compounds | AVISTA PHARMA SOLUTIONS INC (US) | 2020-05-07 | — | — | US | disclosed |
| US-20200138811-A1 | Chemical Compounds | AVISTA PHARMA SOLUTIONS INC (US) | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200138811-A1 | Chemical Compounds | JAK1, JAK3, JAK2 | SIGMAR1 1726/4885ALDH1A1 1175/4885MAPK1 101/4885 |
| US-10744136-B2 | Sulfonamide derivatives as JAK inhibitors | JAK1, JAK3, JAK2 | SIGMAR1 946/4885ALDH1A1 1789/4885MAPK1 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.