Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 20/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21905255 | 0.99 | DHODH (0.81) | DHODH | |
| SCHEMBL21905267 | 0.92 | DHODH (0.79) | DHODH | |
| SCHEMBL20482588 | 0.92 | DHODH (0.79) | DHODH | |
| SCHEMBL21905315 | 0.92 | DHODH (0.79) | DHODH | |
| SCHEMBL21905278 | 0.91 | DHODH (0.81) | DHODH | |
| SCHEMBL30572520 | 0.91 | DHODH (0.77) | DHODH | |
| SCHEMBL21905253 | 0.91 | DHODH (0.77) | DHODH | |
| SCHEMBL30572627 | 0.91 | DHODH (1.00) | DHODH | |
| SCHEMBL21905362 | 0.91 | DHODH (1.00) | DHODH | |
| SCHEMBL21905274 | 0.90 | DHODH (0.82) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3585772-B1 | 1, 4, 6-TRISUBSTITUTED-2-ALKYL-1H-BENZO[D]IMIDAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | MERCK PATENT GMBH (DE) | 2023-10-11 | — | — | EP | claimed |
| US-11028054-B2 | 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors | MERCK PATENT GMBH (DE) | 2021-06-08 | — | — | US | claimed |
| US-20200140395-A1 | 1, 4, 6-TRISUBSTITUTED-2-ALKYL-1H-BENZO[D]IMIDAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | MERCK PATENT GMBH (DE) | 2020-05-07 | — | — | US | claimed |
| EP-3585772-B1 | 1, 4, 6-TRISUBSTITUTED-2-ALKYL-1H-BENZO[D]IMIDAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | MERCK PATENT GMBH (DE) | 2023-10-11 | — | — | EP | disclosed |
| US-11028054-B2 | 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors | MERCK PATENT GMBH (DE) | 2021-06-08 | — | — | US | disclosed |
| US-20200140395-A1 | 1, 4, 6-TRISUBSTITUTED-2-ALKYL-1H-BENZO[D]IMIDAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | MERCK PATENT GMBH (DE) | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200140395-A1 | 1, 4, 6-TRISUBSTITUTED-2-ALKYL-1H-BENZO[D]IMIDAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | DHODH, HAAO, OGDH | DHODH 1/4885 |
| US-11028054-B2 | 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors | DHODH, HAAO, OGDH | DHODH 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.