⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16862541 | 0.86 | NR1H2 (0.39) | — | |
| SCHEMBL23930842 | 0.85 | — | — | |
| SCHEMBL16053196 | 0.84 | KDM4E (0.31) | — | |
| SCHEMBL21906217 | 0.83 | NR1H2 (0.31) | — | |
| SCHEMBL21906221 | 0.83 | — | — | |
| SCHEMBL20973268 | 0.82 | FKBP1A (0.31) | — | |
| SCHEMBL23931000 | 0.82 | FKBP1A (0.31) | — | |
| SCHEMBL23669550 | 0.80 | — | — | |
| SCHEMBL23748291 | 0.80 | — | — | |
| SCHEMBL23670126 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114917361-A | Antibody Drug Conjugates (ADC) and antibody prodrug conjugates (APDC) with enzyme cleavable groups | 拜耳医药股份有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-107635586-B | Antibody-drug conjugates (ADC) of KSP inhibitors with aglycosylated anti-TWEAKR antibodies | 拜耳医药股份有限公司 | 2021-09-24 | — | — | CN | disclosed |
| US-11071788-B2 | Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-07-27 | — | — | US | disclosed |
| CN-106163568-B | Antibody Drug Conjugates (ADC) containing spindle Kinesin (KSP) | 拜耳制药股份公司 | 2021-03-23 | — | — | CN | disclosed |
| US-20200138970-A1 | ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTIB7H3-ANTIBODIES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-05-07 | — | — | US | disclosed |