Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 9/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 15/20 | 0.52 |
| ▸ | AURKA | O14965 | 11/20 | 0.52 |
| ▸ | TPX2 | Q9ULW0 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580385 | 0.84 | TEK (0.60) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580264 | 0.81 | TEK (0.55) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL21908896 | 0.80 | TEK (0.55) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581360 | 0.79 | TEK (0.60) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581511 | 0.79 | TEK (0.60) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL5261884 | 0.77 | AURKB (0.63) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581144 | 0.76 | TEK (0.55) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL974857 | 0.76 | AURKB (0.64) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL1264679 | 0.76 | TEK (0.64) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL1265702 | 0.75 | AURKB (0.68) | TEKAURKBAURKATPX2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020056089-A1 | PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2020-03-19 | — | — | WO | disclosed |