Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 15/20 | 0.64 |
| ▸ | AURKA | O14965 | 11/20 | 0.64 |
| ▸ | TPX2 | Q9ULW0 | 8/20 | 0.64 |
| ▸ | TEK | Q02763 | 8/20 | 0.60 |
| ▸ | KDR | P35968 | 6/20 | 0.57 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265702 | 0.90 | AURKB (0.68) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL973140 | 0.89 | AURKB (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL12423990 | 0.86 | TEK (0.69) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1264644 | 0.85 | AURKB (0.69) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1266413 | 0.85 | TEK (0.77) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1265744 | 0.84 | TEK (0.73) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1264901 | 0.84 | TEK (0.70) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580385 | 0.84 | TEK (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581511 | 0.84 | TEK (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL4825841 | 0.84 | AURKB (0.47) | AURKBAURKATPX2TEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | disclosed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | disclosed |
| EP-1994030-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20070213325-A1 | Multi-cyclic compound and method of use | AMGEN INC. (US) | 2007-09-13 | — | — | US | disclosed |
| WO-2007100646-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213325-A1 | Multi-cyclic compound and method of use | TIE1, CDK1, CCNB1 | AURKB 21/4885AURKA 16/4885TPX2 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.