Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 18/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 10/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28554822 | 1.00 | ERN1 (0.46) | ERN1MAPK10MAPK8MAPK9RET | |
| SCHEMBL25071801 | 1.00 | ERN1 (0.46) | ERN1MAPK10MAPK8MAPK9RET | |
| SCHEMBL28555901 | 0.95 | ERN1 (0.49) | ERN1MAPK10 | |
| SCHEMBL25071795 | 0.95 | ERN1 (0.49) | ERN1MAPK10 | |
| SCHEMBL28551474 | 0.95 | ERN1 (0.48) | ERN1MAPK10 | |
| SCHEMBL21908731 | 0.95 | ERN1 (0.48) | ERN1MAPK10 | |
| SCHEMBL25072096 | 0.95 | ERN1 (0.48) | ERN1MAPK10 | |
| SCHEMBL24435876 | 0.88 | TEK (0.42) | ERN1MAPK10MAPK8MAPK9 | |
| SCHEMBL29633613 | 0.88 | TEK (0.42) | ERN1MAPK10MAPK8MAPK9 | |
| SCHEMBL31145241 | 0.87 | MAPK10 (0.45) | ERN1MAPK10MAPK8MAPK9RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020056089-A1 | PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2020-03-19 | — | — | WO | disclosed |