Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.53 |
| ▸ | SOS1 | Q07889 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21734112 | 0.74 | KRAS (0.55) | KRASSOS1 | |
| SCHEMBL21896268 | 0.73 | KRAS (0.37) | KRASSOS1 | |
| SCHEMBL21733651 | 0.72 | KRAS (0.69) | KRASSOS1 | |
| SCHEMBL29622580 | 0.71 | KRAS (0.56) | KRASSOS1 | |
| SCHEMBL29622208 | 0.71 | KRAS (0.56) | KRASSOS1 | |
| SCHEMBL21895566 | 0.71 | KRAS (0.57) | KRASSOS1 | |
| SCHEMBL21846319 | 0.71 | KRAS (0.46) | KRASSOS1 | |
| SCHEMBL21733771 | 0.70 | KRAS (0.56) | KRASSOS1 | |
| SCHEMBL29568245 | 0.70 | KRAS (0.54) | KRASSOS1 | |
| SCHEMBL29567991 | 0.70 | KRAS (0.54) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055755-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |