Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28840060 | 1.00 | NR1H2 (0.49) | NR1H2HPGDDDB1CRBNUSP2 | |
| Hydrochloric Acid SCHEMBL29596834 | 0.98 | NR1H2 (0.47) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL15313304 | 0.87 | NR1H2 (0.53) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL16759817 | 0.85 | NR1H2 (0.58) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL18082348 | 0.85 | NR1H2 (0.58) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL23906938 | 0.84 | NR1H2 (0.51) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL16080285 | 0.83 | NR1H2 (0.50) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL18115862 | 0.83 | NR1H2 (0.50) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL18115864 | 0.83 | NR1H2 (0.50) | NR1H2HPGDDDB1CRBNUSP2 | |
| SCHEMBL400513 | 0.80 | NR1H2 (0.50) | NR1H2HPGDDDB1CRBNUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250263424-A1 | KRAS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2025-08-21 | — | — | US | disclosed |
| EP-4568952-A1 | KRAS INHIBITORS | Bristol-Myers Squibb Company (US) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024036270-A1 | KRAS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-15 | — | — | WO | disclosed |
| US-20200085791-A1 | [(PHENYLSULFONYL)OCTAHYDRO-EPIMINOISOINDOL-YL](1H-1,2,3-TRIAZOL-5-YL)METHANONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250263424-A1 | KRAS INHIBITORS | KRAS, NRAS, HRAS | NR1H2 3132/4885HPGD 2494/4885DDB1 117/4885 |
| US-20200085791-A1 | [(PHENYLSULFONYL)OCTAHYDRO-EPIMINOISOINDOL-YL](1H-1,2,3-TRIAZOL-5-YL)METHANONES | PKD1, CCND2, SRD5A1 | NR1H2 77/4885HPGD 106/4885DDB1 3633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.