Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 4/20 | 0.34 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21591797 | 0.84 | BRD4 (0.34) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL21591796 | 0.77 | TSHR (0.41) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL22271629 | 0.73 | CHRM1 (0.41) | BRD4 | |
| SCHEMBL9284918 | 0.73 | RECQL (0.37) | BRD4ADORA3TSPODNER | |
| SCHEMBL23348743 | 0.73 | CHRM1 (0.43) | BRD4ADORA3TSPODNER | |
| SCHEMBL23810818 | 0.73 | CHRM1 (0.43) | BRD4ADORA3TSPODNER | |
| SCHEMBL21914871 | 0.71 | BRD4 (0.36) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL9284742 | 0.69 | RECQL (0.43) | BRD4ADORA3TSPODNER | |
| SCHEMBL23728696 | 0.69 | BRD4 (0.60) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL8321508 | 0.69 | CYP11B1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640253-A1 | 6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE | AYUMI Pharmaceutical Corporation (JP) | 2020-04-22 | — | — | EP | disclosed |