Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 5/20 | 0.33 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21591799 | 0.85 | BRD4 (0.33) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL21591798 | 0.77 | TSHR (0.39) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL8319706 | 0.74 | KDM4E (0.35) | — | |
| SCHEMBL21914872 | 0.71 | BRD4 (0.37) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL21847266 | 0.67 | RAB9A (0.39) | — | |
| SCHEMBL21847307 | 0.65 | P2RX7 (0.43) | BRD4 | |
| SCHEMBL28529850 | 0.64 | TSHR (0.39) | BRD4ADORA3TSPOBRD2DNER | |
| SCHEMBL21914670 | 0.63 | TP53 (0.37) | — | |
| SCHEMBL8320823 | 0.61 | HTT (0.33) | BRD4 | |
| SCHEMBL21594280 | 0.60 | BRD4 (0.53) | BRD4ADORA3TSPOBRD2DNER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640253-A1 | 6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE | AYUMI Pharmaceutical Corporation (JP) | 2020-04-22 | — | — | EP | disclosed |