Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHH | Q15465 | 10/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12507950 | 1.00 | SHH (0.73) | SHHALDH1A1MAPT | |
| SCHEMBL2191496 | 1.00 | SHH (0.73) | SHHALDH1A1MAPT | |
| SCHEMBL12418079 | 1.00 | SHH (0.73) | SHHALDH1A1MAPT | |
| SCHEMBL4375725 | 1.00 | SHH (0.73) | SHHALDH1A1MAPT | |
| SCHEMBL17515414 | 0.88 | SHH (0.88) | SHH | |
| SCHEMBL17517675 | 0.88 | SHH (0.88) | SHH | |
| SCHEMBL17497603 | 0.85 | SHH (0.85) | SHH | |
| SCHEMBL12417985 | 0.85 | SHH (0.85) | SHH | |
| Robotnikinin SCHEMBL2187337 | 0.84 | SHH (1.00) | SHH | |
| SCHEMBL17517743 | 0.84 | SHH (0.84) | SHH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-02-18 | — | — | US | disclosed |
| US-8530456-B2 | Sonic hedgehog modulators | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530456-B2 | Sonic hedgehog modulators | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530456-B2 | Sonic hedgehog modulators | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-07-14 | — | — | US | disclosed |
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-07-14 | — | — | US | disclosed |
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-07-14 | — | — | US | disclosed |
| WO-2009132032-A2 | SONIC HEDGEHOG MODULATORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | SHH, GLI1, SMO | SHH 1/4885ALDH1A1 4466/4885MAPT 4165/4885 |
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | SHH, GLI1, SMO | SHH 1/4885ALDH1A1 3382/4885MAPT 4527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.