Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 6/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 6/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20656488 | 0.84 | ADORA2A (0.34) | LMNAADORA2AAXLPRKCIADORA1 | |
| SCHEMBL24117359 | 0.81 | ADORA2A (0.35) | ADORA2AAXLPRKCIADORA1DYRK1A | |
| SCHEMBL17998718 | 0.81 | ADORA2A (0.46) | LMNAADORA2AAXLPRKCIADORA1 | |
| SCHEMBL17998720 | 0.79 | DYRK1A (0.41) | ADORA2AADORA1DYRK1AJAK3 | |
| SCHEMBL681636 | 0.79 | DYRK1A (0.34) | ADORA2AAXLPRKCIADORA1DYRK1A | |
| SCHEMBL21027640 | 0.77 | ADORA2A (0.36) | ADORA2AADORA1DYRK1ATGFBR1 | |
| SCHEMBL20651528 | 0.77 | AXL (0.49) | LMNAADORA2AAXLPRKCIADORA1 | |
| SCHEMBL13906236 | 0.76 | PRKCI (0.52) | ADORA2AAXLPRKCIADORA1DYRK1A | |
| SCHEMBL31275227 | 0.76 | PRKCI (0.52) | ADORA2AAXLPRKCIADORA1DYRK1A | |
| SCHEMBL25776382 | 0.73 | PRKCI (0.36) | LMNAPRKCIDYRK1AJAK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210047311-A1 | HETEROCYCLIC INHIBITORS OF ATR KINASE | ARTIOS PHARMA LIMITED (GB) | 2021-02-18 | — | — | US | disclosed |
| US-10800769-B2 | Heterocyclic inhibitors of ATR kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-10-13 | — | — | US | disclosed |
| US-20200102296-A1 | HETEROCYCLIC INHIBITORS OF ATR KINASE | SHANGPHARMA LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800769-B2 | Heterocyclic inhibitors of ATR kinase | ATR, CHEK1, CHEK2 | LMNA 2072/4885ADORA2A 2989/4885AXL 1195/4885 |
| US-20200102296-A1 | HETEROCYCLIC INHIBITORS OF ATR KINASE | ATR, CHEK1, CHEK2 | LMNA 2072/4885ADORA2A 2989/4885AXL 1195/4885 |
| US-20210047311-A1 | HETEROCYCLIC INHIBITORS OF ATR KINASE | ATR, CHEK1, CHEK2 | LMNA 2072/4885ADORA2A 2989/4885AXL 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.