Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17380078 | 0.82 | DDB1 (0.36) | DDB1CRBNC5AR1NR1H2USP2 | |
| SCHEMBL3623314 | 0.82 | DPP4 (0.37) | DDB1CRBNC5AR1NR1H2USP2 | |
| SCHEMBL17380325 | 0.82 | PARP1 (0.42) | DDB1CRBNNR1H2USP2SMN1; SMN2 | |
| SCHEMBL13250471 | 0.82 | C5AR1 (0.42) | DDB1CRBNC5AR1NR1H2PARP1 | |
| SCHEMBL17380077 | 0.81 | GPR119 (0.36) | DDB1CRBNNR1H2USP2SMN1; SMN2 | |
| SCHEMBL17380144 | 0.81 | DDB1 (0.42) | DDB1CRBNPARP1MAPK1TNKS2 | |
| SCHEMBL17380695 | 0.81 | NR1H2 (0.41) | DDB1CRBNC5AR1NR1H2USP2 | |
| SCHEMBL17380327 | 0.81 | GPR119 (0.39) | DDB1CRBNC5AR1NR1H2USP2 | |
| SCHEMBL17380306 | 0.80 | ADORA1 (0.41) | DDB1CRBNC5AR1SMN1; SMN2MAPT | |
| SCHEMBL17380690 | 0.80 | DDB1 (0.39) | DDB1CRBNC5AR1NR1H2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225479-B2 | Bicyclic inhibitors of histone deacetylase | ALKERMES, INC. (US) | 2022-01-18 | — | — | US | disclosed |
| US-20210122748-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2021-04-29 | — | — | US | disclosed |
| US-10793567-B2 | Bicyclic inhibitors of histone deacetylase | RODIN THERAPEUTICS, INC. (US) | 2020-10-06 | — | — | US | disclosed |
| WO-2018132533-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | RODIN THERAPEUTICS, INC. (US) | 2018-07-19 | — | — | WO | disclosed |
| CN-105531277-B | Pyrrolo-imidazole ring derivatives and their use in medicine | 四川海思科制药有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-105531277-A | Pyrrolo-imidazole ring derivatives and their use in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-04-27 | — | — | CN | disclosed |
| WO-2015192714-A1 | PYRROLOIMIDAZOLE RING DERIVATIVE AND MEDICAL APPLICATION THEREOF | 四川海思科制药有限公司 | 2015-12-23 | — | — | WO | disclosed |
| US-8637491-B2 | Thieno-pyridine derivatives as MEK inhibitors | UCB PHARMA S.A. (BE) | 2014-01-28 | — | — | US | disclosed |
| US-20110172191-A1 | THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS | UCB PHARMA S.A. (BE) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172191-A1 | THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS | MAP2K2, MAP2K1, MAP2K3 | DDB1 1176/4885CRBN 1383/4885C5AR1 2613/4885 |
| US-20210122748-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC3 | DDB1 1903/4885CRBN 1056/4885C5AR1 4682/4885 |
| US-10793567-B2 | Bicyclic inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC11 | DDB1 2017/4885CRBN 1536/4885C5AR1 4626/4885 |
| US-11225479-B2 | Bicyclic inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC3 | DDB1 1903/4885CRBN 1056/4885C5AR1 4682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.