Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.41 |
| ▸ | LPL | P06858 | 8/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30088158 | 1.00 | LIPG (0.41) | LIPGLPLPRMT5WDR77IDO1 | |
| SCHEMBL17644493 | 0.85 | LIPG (0.51) | LIPGLPLPRMT5WDR77HRH3 | |
| SCHEMBL15456756 | 0.80 | LIPG (0.58) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL30863683 | 0.77 | LIPG (0.59) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL806784 | 0.76 | LIPG (0.60) | LIPGLPLIRAK4 | |
| SCHEMBL31456342 | 0.75 | LIPG (0.58) | LIPGLPLIRAK4 | |
| SCHEMBL20023287 | 0.75 | LIPG (0.58) | LIPGLPLIRAK4 | |
| SCHEMBL31456345 | 0.75 | LIPG (0.58) | LIPGLPLIRAK4 | |
| SCHEMBL20658766 | 0.75 | LIPG (0.51) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL25681062 | 0.75 | LIPG (0.56) | LIPGLPLPRMT5WDR77IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113015526-A | Spirocyclic 2, 3-dihydro-7-azaindole compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |