Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21920774 | 0.70 | — | — | |
| SCHEMBL21919955 | 0.68 | MAP4K1 (0.40) | — | |
| SCHEMBL30087946 | 0.66 | MAP4K1 (0.45) | CYP1A2TSHRLMNA | |
| SCHEMBL21919863 | 0.66 | MAP4K1 (0.45) | CYP1A2TSHRLMNA | |
| SCHEMBL28614186 | 0.66 | MAP4K1 (0.45) | CYP1A2TSHRLMNA | |
| Hydrochloric Acid SCHEMBL30088084 | 0.65 | MAP4K1 (0.44) | — | |
| SCHEMBL14530738 | 0.64 | NNMT (0.38) | NNMT | |
| SCHEMBL21920327 | 0.62 | MAP4K1 (0.48) | NNMT | |
| SCHEMBL21920324 | 0.62 | MAP4K1 (0.48) | NNMT | |
| SCHEMBL30087806 | 0.62 | MAP4K1 (0.48) | NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |