Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CCL2 | P13500 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21925208 | 0.89 | MAPT (0.58) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL19542004 | 0.80 | MAPT (0.62) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL8257960 | 0.78 | HRH3 (0.54) | HRH3HTTSMN1; SMN2NCF1ALDH1A1 | |
| SCHEMBL31082081 | 0.75 | HRH3 (0.51) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL26351809 | 0.75 | HRH3 (0.47) | HRH3HTTSMN1; SMN2NCF1ALDH1A1 | |
| SCHEMBL23235186 | 0.75 | HRH3 (0.54) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL17724130 | 0.75 | HRH3 (0.54) | HRH3HTTSMN1; SMN2NCF1ALDH1A1 | |
| SCHEMBL18491483 | 0.75 | HRH3 (0.54) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL538318 | 0.75 | HTT (0.58) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL632550 | 0.75 | HRH3 (0.59) | HRH3HTTSMN1; SMN2NCF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Kangpu Biopharmaceuticals, Ltd. (CN) | 2020-04-29 | — | — | EP | disclosed |