Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21925208 | 0.88 | MAPT (0.58) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL21776343 | 0.86 | ALDH1A1 (0.63) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL24302659 | 0.82 | MAPT (0.43) | MAPTHTTALDH1A1TSHR | |
| SCHEMBL12295183 | 0.82 | MAPT (0.62) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL17724130 | 0.80 | HRH3 (0.54) | HRH3HTTSMN1; SMN2NCF1ALDH1A1 | |
| SCHEMBL8257960 | 0.80 | HRH3 (0.54) | HRH3HTTSMN1; SMN2NCF1ALDH1A1 | |
| SCHEMBL21924136 | 0.80 | MAPT (0.49) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL13122710 | 0.79 | MAPT (0.55) | MAPTHRH3HTTSMN1; SMN2NCF1 | |
| SCHEMBL1552775 | 0.78 | HRH3 (0.61) | HRH3HTTSMN1; SMN2NCF1ALDH1A1 | |
| SCHEMBL20605142 | 0.78 | HRH3 (0.51) | MAPTHRH3HTTSMN1; SMN2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017492-B2 | Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof | KANGPU BIOPHARMACEUTICALS, LTD. (CN) | 2018-07-10 | — | — | US | disclosed |
| US-20170313676-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS, LTD. (CN) | 2017-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10017492-B2 | Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof | IL2, IL1B, IL5 | MAPT 1185/4885HRH3 1625/4885HTT 1981/4885 |
| US-20170313676-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | IL2, IL1B, IL5 | MAPT 1185/4885HRH3 1625/4885HTT 1981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.