Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.90 |
| ▸ | HTR1A | P08908 | 2/20 | 0.77 |
| ▸ | HTR2A | P28223 | 1/20 | 0.77 |
| ▸ | HTR7 | P34969 | 1/20 | 0.77 |
| ▸ | HTR6 | P50406 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.74 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | RAD52 | P43351 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.60 |
| ▸ | YAP1 | P46937 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24113921 | 1.00 | MAPT (0.90) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL16433498 | 0.87 | MAPT (0.86) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL15278242 | 0.87 | HTR1A (1.00) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL4152125 | 0.86 | HTR1A (0.76) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL4170361 | 0.86 | MAPT (0.83) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL4164222 | 0.80 | RAD52 (0.75) | MAPTHTR1AKDM4EHSD17B10PAX8 | |
| SCHEMBL4152515 | 0.80 | HTR1A (0.67) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL24113877 | 0.80 | MAPT (0.66) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL10005901 | 0.79 | MAPT (0.73) | MAPTHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL11982788 | 0.79 | KDM4E (0.72) | MAPTHTR1AKDM4EHSD17B10PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008327-B2 | Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2021-05-18 | — | — | US | disclosed |
| US-20200131186-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008327-B2 | Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole | PIR, DRD5, DRD1 | MAPT 2712/4885HTR1A 63/4885HTR2A 379/4885 |
| US-20200131186-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | PIR, CYP3A5, DRD5 | MAPT 2680/4885HTR1A 134/4885HTR2A 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.