SCHEMBL219318

SCHEMBL219318

COc1[c]cc(OC)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.42
NPC1 O15118 1/20 0.42
TAAR1 Q96RJ0 1/20 0.40
ACHE P22303 1/20 0.38
ALDH1A1 P00352 5/20 0.38
MAPT P10636 5/20 0.38
NPSR1 Q6W5P4 4/20 0.38
MAPK1 P28482 2/20 0.38
RAB9A P51151 2/20 0.38
HSP90AA1 P07900 1/20 0.38
PKM P14618 1/20 0.38
CCR6 P51684 1/20 0.38
CACNA1B Q00975 1/20 0.38
APBA1 Q02410 1/20 0.38
APOBEC3G Q9HC16 1/20 0.38
KDM4E B2RXH2 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
USP2 O75604 2/20 0.33
POLB P06746 2/20 0.33
HPGD P15428 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL358784 0.83 GAA (0.42) GAANPC1TAAR1ACHEALDH1A1
SCHEMBL1028624 0.82 GAA (0.31) GAANPC1TAAR1
SCHEMBL1095882 0.80 GAA (0.43) GAANPC1TAAR1ACHEALDH1A1
SCHEMBL592705 0.79 CYP3A4 (0.39) ACHEALDH1A1MAPTKDM4ESMN1; SMN2
SCHEMBL1526163 0.78 KDM4E (0.33) NPC1ALDH1A1MAPTNPSR1RAB9A
SCHEMBL1097066 0.77 GAA (0.41) GAANPC1TAAR1ACHEALDH1A1
SCHEMBL2348836 0.77 MAPT (0.32) NPC1TAAR1ALDH1A1MAPTRAB9A
SCHEMBL718547 0.77 NPC1 (0.41) GAANPC1TAAR1ACHEALDH1A1
SCHEMBL1965077 0.77 GAA (0.41) GAANPC1TAAR1ACHEALDH1A1
SCHEMBL1969378 0.76 ACHE (0.39) NPC1TAAR1ACHEMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 418 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105287388-B High dispersive carbazole sulfonamide derivative and preparation method thereof 山西普德药业有限公司 2019-09-17 CN claimed
CN-109851550-A 7- aminocarbazole sulfamide derivative and its preparation method and application 中国医学科学院医药生物技术研究所 2019-06-07 CN claimed
CN-105418487-B Carbazole sulfonamide derivative eutectic and preparation method thereof 山西普德药业有限公司 2018-11-02 CN claimed
CN-106545541-B A kind of remote control type Suporting structure hydraulic locking apparatus and its method of work 徐州工程学院 2017-12-29 CN claimed
CN-104306168-B Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth 华东师范大学 2017-05-24 CN claimed
CN-106566280-A Coated pigment composition and production method thereof DIC株式会社 2017-04-19 CN claimed
CN-106545541-A A kind of remote control type Suporting structure hydraulic locking apparatus and its method of work 徐州工程学院 2017-03-29 CN claimed
EP-2167492-B1 NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS HANMI SCIENCE CO LTD (KR) 2015-10-14 EP claimed
US-8188102-B2 Amide derivative for inhibiting the growth of cancer cells HANMI HOLDINGS CO., LTD. (KR) 2012-05-29 US claimed
CN-101287734-B 2-amino-7, 8-dihydro-6H-pyrido [4,3-d ] pyrimidin-5-ones NOVARTIS AG 2011-07-20 CN claimed
EP-0055850-B1 DISAZO COMPOUNDS, METHODS FOR THEIR PREPARATION AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1984-08-01 EP claimed
US-4440845-A CHARGE TRANSFER COMPOUND RICOH CO., LTD. (JP) 1984-04-03 US claimed
US-4427753-A Electrophotographic photosensitive member with disazo or trisazo compound CANON KABUSHIKI KAISHA (JP) 1984-01-24 US claimed
EP-0012611-B1 ELECTROPHOTOGRAPHIC ELEMENT Ricoh Company, Ltd (JP) 1983-10-05 EP claimed
EP-0013172-B1 ELECTROPHOTOGRAPHIC ELEMENTS Ricoh Company, Ltd (JP) 1983-09-07 EP claimed
EP-0055850-A2 Disazo compounds, methods for their preparation and their use HOECHST AKTIENGESELLSCHAFT (DE) 1982-07-14 EP claimed
EP-0013172-A2 Electrophotographic elements Ricoh Company, Ltd (JP) 1980-07-09 EP claimed
EP-0012611-A2 Electrophotographic element Ricoh Company, Ltd (JP) 1980-06-25 EP claimed
US-4041036-A NAPHTHO(1',2':5,6)-PYRANO(2,3-D)PYRIMIDINE DYES HOECHST AKTIENGESELLSCHAFT (DT) 1977-08-09 US claimed
US-3947516-A Novel aromatic aldehydes and process for preparing them HOECHST AKTIENGESELLSCHAFT (DT) 1976-03-30 US claimed