Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.75 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.75 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.75 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.75 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.75 |
| ▸ | GPR183 | P32249 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12420493 | 0.92 | S1PR1 (0.75) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| SCHEMBL12670145 | 0.88 | S1PR1 (0.74) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| SCHEMBL12669584 | 0.88 | S1PR1 (0.69) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| SCHEMBL19575327 | 0.87 | S1PR1 (0.84) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| SCHEMBL22280106 | 0.87 | S1PR1 (0.77) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| SCHEMBL19575326 | 0.87 | S1PR1 (0.84) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| SCHEMBL13417204 | 0.87 | S1PR1 (0.84) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| Hydrochloric Acid SCHEMBL31424222 | 0.86 | S1PR1 (0.85) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| Ozanimod SCHEMBL2195490 | 0.86 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5S1PR2 | |
| Ozanimod SCHEMBL1413256 | 0.86 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3406142-B1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | CELGENE INT II SARL (CH) | 2020-12-23 | — | — | EP | disclosed |
| EP-3406142-B1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | CELGENE INT II SARL (CH) | 2020-12-23 | — | — | EP | disclosed |
| US-20190224172-A1 | COMPOUNDS AND METHODS FOR TREATING LUPUS | RECEPTOS LLC | 2019-07-25 | — | — | US | disclosed |
| US-10239846-B2 | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | CELGENE INTERNATIONAL II SÀRL (CH) | 2019-03-26 | — | — | US | disclosed |
| US-10239846-B2 | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | CELGENE INTERNATIONAL II SÀRL (CH) | 2019-03-26 | — | — | US | disclosed |
| EP-3406142-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | Celgene International II Sàrl (CH) | 2018-11-28 | — | — | EP | disclosed |
| WO-2018064356-A1 | COMPOUNDS AND METHODS FOR TREATING LUPUS | CELGENE INTERNATIONAL II SARL (CH) | 2018-04-05 | — | — | WO | disclosed |
| US-20170320839-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2017-11-09 | — | — | US | disclosed |
| US-20170320839-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2017-11-09 | — | — | US | disclosed |
| US-20170320839-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2017-11-09 | — | — | US | disclosed |
| US-20130231326-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231326-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231326-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8362048-B2 | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-8362048-B2 | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-8362048-B2 | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20110172202-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2011-07-14 | — | — | US | disclosed |
| US-20110172202-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2011-07-14 | — | — | US | disclosed |
| US-20110172202-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2011-07-14 | — | — | US | disclosed |
| WO-2011060392-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190224172-A1 | COMPOUNDS AND METHODS FOR TREATING LUPUS | S1PR1, S1PR2, SSB | S1PR1 1/4885S1PR4 5/4885S1PR3 4/4885 |
| US-20110172202-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR4 4/4885S1PR3 2/4885 |
| US-20170320839-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR4 4/4885S1PR3 2/4885 |
| US-10239846-B2 | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR4 4/4885S1PR3 2/4885 |
| US-20130231326-A1 | SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR4 4/4885S1PR3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.