⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21932888 | 0.84 | IKZF2 (0.33) | — | |
| SCHEMBL21932872 | 0.83 | PDE3B (0.30) | — | |
| SCHEMBL21932867 | 0.80 | — | — | |
| SCHEMBL28625447 | 0.77 | HTR2C (0.37) | — | |
| SCHEMBL21932896 | 0.74 | IKZF2 (0.42) | — | |
| SCHEMBL21932917 | 0.73 | CRBN (0.52) | — | |
| SCHEMBL22000914 | 0.72 | CRBN (0.51) | — | |
| SCHEMBL22001054 | 0.72 | CRBN (0.32) | — | |
| SCHEMBL22000761 | 0.72 | CRBN (0.51) | — | |
| SCHEMBL22000917 | 0.71 | CRBN (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352338-B2 | Substituted isoindolinones | BIOTHERYX, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| EP-3880669-A1 | SUBSTITUTED ISOINDOLINONES | Biotheryx, Inc. (US) | 2021-09-22 | — | — | EP | disclosed |
| CN-113423701-A | Substituted isoindolinones | 拜欧斯瑞克斯公司 | 2021-09-21 | — | — | CN | disclosed |
| US-10844039-B2 | Substituted isoindolinones | BIOTHERYX, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200325114-A1 | SUBSTITUTED ISOINDOLINONES | BIOTHERYX, INC. (US) | 2020-10-15 | — | — | US | disclosed |
| WO-2020102195-A1 | SUBSTITUTED ISOINDOLINONES | BIOTHERYX, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| US-20200148663-A1 | SUBSTITUTED ISOINDOLINONES | BIOTHERYX, INC. | 2020-05-14 | — | — | US | disclosed |