⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21906680 | 0.92 | — | — | |
| SCHEMBL21214940 | 0.86 | GBA2 (0.32) | — | |
| SCHEMBL21106247 | 0.83 | KDM4E (0.36) | — | |
| SCHEMBL25725953 | 0.83 | HRH3 (0.31) | — | |
| SCHEMBL24925547 | 0.83 | TSHR (0.33) | — | |
| SCHEMBL26457722 | 0.81 | — | — | |
| SCHEMBL16944223 | 0.81 | TSHR (0.36) | — | |
| SCHEMBL23341229 | 0.80 | HRH3 (0.32) | — | |
| SCHEMBL24763974 | 0.79 | HRH3 (0.36) | — | |
| SCHEMBL25725972 | 0.79 | HRH3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230000994-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | YALE UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
| US-11173211-B2 | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides | ARVINAS OPERATIONS, INC. (US) | 2021-11-16 | — | — | US | disclosed |
| US-20200129627-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2020-04-30 | — | — | US | disclosed |