Citric Acid

Citric Acid

SCHEMBL21936

O=C(O)CC(O)(CC(=O)O)C(=O)O.[Cu]

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.41
ALDH1A1 P00352 2/20 0.94
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
ACLY P53396 4/20 0.44
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
SLC13A5 Q86YT5 4/20 0.42
CPT2 P23786 1/20 0.42
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL29354261 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL688613 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL896563 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL5246321 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3958240 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL16149967 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL5425793 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7529951 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL524515 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL524764 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6796 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122082060-A Preparation method of high-corrosion-resistance electroplated copper on carbon steel surface 2026-05-26 CN claimed
CN-115820316-B Coal-saving catalyst for thermal power plant and preparation method thereof NANJING YONGNENG MATERIALS CO.,LTD. (CN) 2026-05-26 CN claimed
CN-122071001-A Catalyst and method for preparing organic carboxylic acid by catalytic oxidation of aldehyde 万华化学集团股份有限公司 2026-05-22 CN claimed
US-20260130785-A1 SYSTEMS AND METHODS INCLUDING LUBRICANTS FOR CONVEYANCE OF STOOL LIQUIGLIDE INC (US) 2026-05-14 US claimed
CN-122005437-A Copper ion hydrogel and preparation method and application thereof 陕西科技大学 2026-05-12 CN claimed
EP-4724077-A1 COMBINATION OF BACTERIAL STRAINS TO INHIBIT PATHOGENS IN ANIMALS Phibro Animal Health Corporation (US) 2026-04-15 EP claimed
EP-4719294-A1 SYSTEMS AND METHODS INCLUDING LUBRICANTS FOR CONVEYANCE OF STOOL Liquiglide Inc. (US) 2026-04-08 EP claimed
US-20260092186-A1 METAL NANOPARTICLE INK UNIV IOWA STATE RES FOUND INC (US) 2026-04-02 US claimed
US-20260077020-A1 ORAL PEPTIDE PHARMACEUTICAL COMPOSITION THAT FACILITATES ENHANCED ORAL ABSORPTION LE ROUX DANIELLE MARIE (US) 2026-03-19 US claimed
US-20260035583-A1 IN-SITU THERMALLY ACTIVATED IONIC INK, AND PREPARATION METHOD AND APPLICATION THEREOF UNIV GUANGDONG TECHNOLOGY (CN) 2026-02-05 US claimed
EP-0004570-B1 THIOL ESTERS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS USING THE SAME Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1982-04-14 EP claimed
US-4308118-A POLYEPOXIDES; IRRADIATION POLYMERIZATION GENERAL ELECTRIC COMPANY (US) 1981-12-29 US claimed
US-4275190-A VARNISHES AND FREE-FLOWING POWDERS STABILIZED WITH CARBOXYLATED OR HYDROXYLATED ACRYLONITRILE-BUTADIENE COPOLYMER GENERAL ELECTRIC COMPANY (US) 1981-06-23 US claimed
US-4254214-A BLACK, REDUCTION OF COPPER SALT OR COMPLEX TO COPPER FUJI PHOTO FILM CO., LTD. (JP) 1981-03-03 US claimed
US-4238563-A COPPER SALT, FERRICYANIDE SALT, SEQUESTERING AGENT MINRAD CORPORATION (US) 1980-12-09 US claimed
US-4173453-A Topical hair coloring formulation in the form of suspension, lotion and cream CDC Research Inc. (US) 1979-11-06 US claimed
EP-0004570-A1 Thiol esters, process for their preparation, pharmaceutical compositions containing them and a process for preparing cephalosporin compounds using the same Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1979-10-17 EP claimed
US-4100204-A Oxidative coupling of alkylphenols or 1-naphthols catalyzed by metal complexes of a hydroxy- or keto-acid compound ICI AMERICAS INC. (US) 1978-07-11 US claimed
US-4007316-A COATED WITH COPPER OXALATE, SULFUR, CARBON THE MAGNAVOX COMPANY (US) 1977-02-08 US claimed
US-3997525-A Tetra-125 iodo-di-tyramine of digitalis derivative and process for making the same BIO-TEC, INC. (US) 1976-12-14 US claimed