Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 8/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194148 | 1.00 | SCN3A (0.46) | SCN3ASCN9ADPP4DPP8JAK2 | |
| SCHEMBL14664066 | 0.87 | SMO (0.46) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL13570409 | 0.87 | SMO (0.46) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL12490017 | 0.86 | SMO (0.45) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL13571673 | 0.86 | ALDH1A1 (0.47) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL12489110 | 0.86 | SCN3A (0.59) | SCN3ASCN9AJAK2PDGFRBFLT3 | |
| SCHEMBL14828738 | 0.86 | SCN3A (0.59) | SCN3ASCN9AJAK2PDGFRBFLT3 | |
| SCHEMBL13570367 | 0.85 | CNR2 (0.48) | JAK1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL2196787 | 0.85 | ALDH1A1 (0.49) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL2194270 | 0.83 | MEN1 (0.44) | JAK2KDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362020-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | claimed |
| EP-2519506-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-11-07 | — | — | EP | claimed |
| WO-2011082077-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-07-07 | — | — | WO | claimed |