Sugi Predict

Sugi Predict / Compounds / SCHEMBL2193909

SCHEMBL2193909

SCHEMBL2193909

COc1ccc(C(=O)Nc2ccc(-c3cn4cc(C)ccc4n3)cc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 10/20 0.65
▸ RAB9A P51151 10/20 0.65
▸ KDM4E B2RXH2 7/20 0.65
▸ ALDH1A1 P00352 7/20 0.65
▸ POLB P06746 2/20 0.65
▸ GAA P10253 1/20 0.65
▸ SMN1; SMN2 Q16637 6/20 0.65
▸ HPGD P15428 5/20 0.65
▸ KMT2A Q03164 5/20 0.59
▸ MEN1 O00255 4/20 0.59
▸ L3MBTL1 Q9Y468 2/20 0.59
▸ LMNA P02545 2/20 0.58
▸ MAPT P10636 1/20 0.58
▸ ALDH1A3 P47895 3/20 0.56
▸ TP53 P04637 1/20 0.56
▸ ALOX15 P16050 1/20 0.56
▸ SNCA P37840 1/20 0.55
▸ ADRB2 P07550 1/20 0.55
▸ TMIGD3 P0DMS9 2/20 0.54
▸ CYP2C19 P33261 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16623339 0.91 NPC1 (0.74) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL2194816 0.87 NPC1 (0.70) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL2194530 0.87 NPC1 (0.70) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL12422039 0.87 KDM4E (0.60) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL2193852 0.86 NPC1 (0.68) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL1984261 0.86 SMN1; SMN2 (0.71) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL1494815 0.86 KDM4E (0.74) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL12509330 0.85 NPC1 (0.67) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL2196182 0.85 NPC1 (0.70) NPC1RAB9AKDM4EALDH1A1POLB
SCHEMBL2197255 0.84 APP (0.69) NPC1RAB9AKDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2338059-B1 Ligands for aggregated tau molecules WISTA LAB LTD (SG) 2015-04-08 — — EP disclosed
EP-2338059-B1 Ligands for aggregated tau molecules WISTA LAB LTD (SG) 2015-04-08 — — EP disclosed
US-8895313-B2 Ligands for aggregated tau molecules WISTA LABORATORIES LTD. (SG) 2014-11-25 — — US disclosed
US-8895313-B2 Ligands for aggregated tau molecules WISTA LABORATORIES LTD. (SG) 2014-11-25 — — US disclosed
US-8895313-B2 Ligands for aggregated tau molecules WISTA LABORATORIES LTD. (SG) 2014-11-25 — — US disclosed
US-20110171739-A1 LIGANDS FOR AGGREGATED TAU MOLECULES WISTA LABORATORIES LTD. 2011-07-14 — — US disclosed
US-20110171739-A1 LIGANDS FOR AGGREGATED TAU MOLECULES WISTA LABORATORIES LTD. 2011-07-14 — — US disclosed
US-20110171739-A1 LIGANDS FOR AGGREGATED TAU MOLECULES WISTA LABORATORIES LTD. 2011-07-14 — — US disclosed
WO-2010034982-A1 LIGANDS FOR AGGREGATED TAU MOLECULES WISTA LABORATORIES LTD. (SG) 2010-04-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171739-A1 LIGANDS FOR AGGREGATED TAU MOLECULES MAPT, PRNP, MAP4 NPC1 1265/4885RAB9A 2622/4885KDM4E 4073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.