Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.74 |
| ▸ | RAB9A | P51151 | 11/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.74 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.64 |
| ▸ | KDM5A | P29375 | 1/20 | 0.64 |
| ▸ | KDM5C | P41229 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.56 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194530 | 0.94 | NPC1 (0.70) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2194816 | 0.94 | NPC1 (0.70) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2193852 | 0.93 | NPC1 (0.68) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1984261 | 0.93 | SMN1; SMN2 (0.71) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12509330 | 0.92 | NPC1 (0.67) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2196182 | 0.91 | NPC1 (0.70) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2193909 | 0.91 | NPC1 (0.65) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2197255 | 0.91 | APP (0.69) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2193894 | 0.89 | RAB9A (0.63) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12422138 | 0.87 | SMN1; SMN2 (0.64) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338059-B1 | Ligands for aggregated tau molecules | WISTA LAB LTD (SG) | 2015-04-08 | — | — | EP | disclosed |