Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 20/20 | 0.67 |
| ▸ | CRBN | Q96SW2 | 20/20 | 0.67 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.67 |
| ▸ | TNF | P01375 | 1/20 | 0.67 |
| ▸ | IL1B | P01584 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2603174 | 0.89 | DDB1 (0.70) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL26317880 | 0.88 | DDB1 (0.69) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL25475645 | 0.88 | DDB1 (0.74) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL14218469 | 0.88 | DDB1 (0.74) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL30572353 | 0.86 | CRBN (0.67) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18904277 | 0.86 | DDB1 (0.75) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18945872 | 0.86 | DDB1 (0.75) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL283241 | 0.86 | DDB1 (0.75) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL26318074 | 0.85 | CRBN (0.66) | DDB1CRBNIKZF3TNFIL1B | |
| Hydrochloric Acid SCHEMBL284302 | 0.85 | DDB1 (0.74) | DDB1CRBNIKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081682-A1 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |