Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 13/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21941069 | 0.84 | SOS1 (0.37) | PRMT5WDR77S1PR2CYP2C19CYP3A4 | |
| SCHEMBL21940285 | 0.80 | S1PR2 (0.40) | IDH1S1PR2CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL20606921 | 0.79 | S1PR2 (0.49) | PRMT5WDR77S1PR2CYP2C19CYP3A4 | |
| Hydrochloric Acid SCHEMBL20606941 | 0.78 | S1PR2 (0.48) | PRMT5WDR77S1PR2CYP2C19CYP3A4 | |
| SCHEMBL21819818 | 0.76 | PRMT5 (0.39) | IDH1PRMT5WDR77S1PR2CYP2C19 | |
| SCHEMBL21941072 | 0.76 | S1PR2 (0.41) | PRMT5WDR77S1PR2CYP2C19CYP3A4 | |
| SCHEMBL21940289 | 0.76 | PRMT5 (0.40) | IDH1PRMT5WDR77S1PR2CYP2C19 | |
| SCHEMBL21940575 | 0.74 | S1PR2 (0.39) | PRMT5WDR77S1PR2CYP2C19CYP3A4 | |
| SCHEMBL21940577 | 0.68 | PRMT5 (0.45) | PRMT5WDR77S1PR2CYP2C19CYP3A4 | |
| SCHEMBL21940505 | 0.63 | CHRM4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |