Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 10/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940283 | 0.84 | IDH1 (0.37) | PRMT5WDR77CYP3A4CYP2C19S1PR2 | |
| SCHEMBL21940576 | 0.81 | KDM4E (0.39) | SOS1PIK3CDWDR5CYP3A4CYP2C19 | |
| SCHEMBL20606921 | 0.78 | S1PR2 (0.49) | PRMT5WDR77CYP3A4CYP2C19S1PR2 | |
| Hydrochloric Acid SCHEMBL20606941 | 0.77 | S1PR2 (0.48) | PRMT5WDR77CYP3A4CYP2C19S1PR2 | |
| SCHEMBL21819818 | 0.76 | PRMT5 (0.39) | PRMT5WDR77WDR5CYP3A4CYP2C19 | |
| SCHEMBL21940289 | 0.75 | PRMT5 (0.40) | PRMT5WDR77CYP3A4CYP2C19S1PR2 | |
| SCHEMBL21941072 | 0.75 | S1PR2 (0.41) | PRMT5WDR77CYP3A4CYP2C19S1PR2 | |
| SCHEMBL21940575 | 0.73 | S1PR2 (0.39) | PRMT5WDR77CYP3A4CYP2C19S1PR2 | |
| SCHEMBL21940476 | 0.68 | S1PR2 (0.37) | S1PR2LRRK2 | |
| SCHEMBL21940577 | 0.67 | PRMT5 (0.45) | PRMT5WDR77CYP3A4CYP2C19S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |