Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20606970 | 0.85 | — | — | |
| SCHEMBL21940798 | 0.80 | — | — | |
| SCHEMBL21941071 | 0.78 | S1PR2 (0.34) | — | |
| SCHEMBL24299650 | 0.73 | IRAK4 (0.41) | CHRM2CHRM4CHRM5CHRM3IRAK4 | |
| SCHEMBL15034179 | 0.71 | CHRM2 (0.37) | CHRM2CHRM4CHRM5CHRM3L3MBTL1 | |
| SCHEMBL6989663 | 0.69 | LRRK2 (0.36) | L3MBTL1 | |
| SCHEMBL30106951 | 0.69 | IDH1 (0.41) | — | |
| SCHEMBL25745838 | 0.68 | PIM1 (0.38) | — | |
| SCHEMBL31521633 | 0.68 | — | — | |
| SCHEMBL31521630 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |