Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996622 | 0.82 | GAA (0.31) | LMNAGAA | |
| SCHEMBL12926057 | 0.82 | HTT (0.37) | HTTSMN1; SMN2ALDH1A1L3MBTL1RECQL | |
| SCHEMBL6990551 | 0.79 | GAA (0.38) | LRRK2L3MBTL1GAANPC1KLKB1 | |
| SCHEMBL12121226 | 0.79 | P2RX7 (0.40) | LRRK2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL24240629 | 0.78 | L3MBTL1 (0.40) | LRRK2CYP1A2HTTALDH1A1L3MBTL1 | |
| SCHEMBL17066899 | 0.78 | NPC1 (0.44) | LRRK2CYP1A2HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21281610 | 0.78 | HTT (0.35) | LRRK2CYP1A2HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8322882 | 0.78 | RECQL (0.35) | LRRK2CYP1A2HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL24013536 | 0.78 | LRRK2 (0.33) | LRRK2CYP1A2HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15684076 | 0.78 | GAA (0.32) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220218688-A1 | PYRIDYLPYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2022-07-14 | — | — | US | disclosed |
| EP-3672941-B1 | PYRIDYLPYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2022-02-09 | — | — | EP | disclosed |
| US-20210361774-A1 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-11-25 | — | — | US | disclosed |
| WO-2020247679-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY (US) | 2020-12-10 | — | — | WO | disclosed |
| WO-2019038387-A1 | PYRIDYLPYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2019-02-28 | — | — | WO | disclosed |
| WO-2015089131-A1 | ALKYLPYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2015-06-18 | — | — | WO | disclosed |
| US-8207207-B2 | Heterocyclic a amide derivatives useful as microbiocides | SYNGENTA CROP PROTECTION LLC (US) | 2012-06-26 | — | — | US | disclosed |
| US-8183416-B2 | Heterocyclic amide derivatives useful as microbiocides | SYNGENTA CROP PROTECTION, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-7994093-B2 | Heterocyclocarboxamide derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-20100204482-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100204287-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-7732469-B2 | for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-08 | — | — | US | disclosed |
| US-20100010063-A1 | HETEROCYCLOCARBOXAMIDE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-7598395-B2 | Tricyclic amine derivatives such as 3-Difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide; fungicides; horticulture | SYNGENTA CROP PROTECTION, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20080227835-A1 | Heterocyclic Amide Derivatives Useful as Microbiocides | SYNGENTA CROP PROTECTION, INC. (US) | 2008-09-18 | — | — | US | disclosed |
| US-20080051446-A1 | Heterocyclocarboxamide Derivatives | SYNGENTA CROP PROTECTION, INC. | 2008-02-28 | — | — | US | disclosed |
| WO-2007048556-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010063-A1 | HETEROCYCLOCARBOXAMIDE DERIVATIVES | CBR3, CBR1, NOX1 | LRRK2 2808/4885CYP1A2 116/4885HTT 1728/4885 |
| US-20100204482-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | CBR3, CBR1, CYP8B1 | LRRK2 4380/4885CYP1A2 133/4885HTT 1861/4885 |
| US-20210361774-A1 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | LRRK2, CLK2, DDRGK1 | LRRK2 1/4885CYP1A2 2552/4885HTT 408/4885 |
| US-20080051446-A1 | Heterocyclocarboxamide Derivatives | CBR3, CBR1, NOX1 | LRRK2 2808/4885CYP1A2 116/4885HTT 1728/4885 |
| US-20100204287-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | CBR3, CBR1, CYP8B1 | LRRK2 4302/4885CYP1A2 177/4885HTT 1625/4885 |
| US-20220218688-A1 | PYRIDYLPYRIDONE COMPOUNDS | PDXK, PLPBP, PNPO | LRRK2 895/4885CYP1A2 354/4885HTT 2126/4885 |
| US-20080227835-A1 | Heterocyclic Amide Derivatives Useful as Microbiocides | CBR3, CBR1, CYP8B1 | LRRK2 4185/4885CYP1A2 130/4885HTT 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.