Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | KRAS | P01116 | 2/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940466 | 0.92 | SYK (0.44) | SOS1HDAC6GRM5SYK | |
| SCHEMBL21940313 | 0.78 | MCHR1 (0.43) | GRM5P2RX3P2RX2 | |
| SCHEMBL25409208 | 0.78 | IRAK4 (0.41) | SOS1CYP3A4CYP2D6CYP2C19KCNH2 | |
| SCHEMBL1263834 | 0.76 | SOS1 (0.46) | SOS1CYP3A4CYP2D6KRASCYP2C8 | |
| SCHEMBL5423541 | 0.76 | SOS1 (0.46) | SOS1CYP3A4CYP2D6KRASCYP2C8 | |
| SCHEMBL12382084 | 0.74 | SOS1 (0.40) | SOS1CYP3A4CYP2D6KRASCYP2C8 | |
| SCHEMBL17581321 | 0.73 | PIK3CA (0.40) | SOS1CYP3A4CYP2D6KRASCYP2C19 | |
| SCHEMBL6826046 | 0.73 | PIK3CA (0.41) | AKT1PIK3CAMTORMAPK8MAPK9 | |
| SCHEMBL24566255 | 0.73 | TLR7 (0.35) | PIK3CAMTOR | |
| SCHEMBL17581280 | 0.73 | PIK3CA (0.40) | SOS1CYP3A4CYP2D6KRASCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |