Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 12/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940878 | 1.00 | SLC6A3 (0.38) | SLC6A3SLC6A2SLC6A4PTPN11KCNH2 | |
| SCHEMBL22523798 | 0.85 | CYP2D6 (0.41) | PTPN11KCNH2AADAT | |
| SCHEMBL24091164 | 0.85 | KMT2A (0.40) | PTPN11KCNH2AADATOPRM1OPRK1 | |
| SCHEMBL24879252 | 0.85 | CYP2D6 (0.41) | PTPN11KCNH2AADAT | |
| SCHEMBL22523803 | 0.85 | KCNH2 (0.41) | PTPN11KCNH2AADATOPRM1 | |
| SCHEMBL24091090 | 0.85 | KCNH2 (0.41) | PTPN11KCNH2AADATOPRM1 | |
| SCHEMBL23508941 | 0.84 | KCNH2 (0.41) | PTPN11KCNH2AADAT | |
| SCHEMBL21940606 | 0.84 | PTPN11 (0.43) | PTPN11KCNH2HTR2BADRA2A | |
| SCHEMBL21940609 | 0.84 | PTPN11 (0.43) | PTPN11KCNH2HTR2BADRA2A | |
| SCHEMBL24388825 | 0.82 | SLC6A2 (0.42) | SLC6A3SLC6A2SLC6A4AADATHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3867238-B1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2020081848-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-04-23 | — | — | WO | disclosed |