Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20606768 | 0.88 | LRRK2 (0.40) | ALDH1A1HPGDKDM4EHSD17B10RECQL | |
| SCHEMBL21941079 | 0.77 | LRRK2 (0.38) | ALDH1A1HPGDKDM4EHSD17B10RECQL | |
| SCHEMBL21940582 | 0.73 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10TSHR | |
| SCHEMBL21940293 | 0.73 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10TSHR | |
| SCHEMBL21940800 | 0.73 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10TSHR | |
| SCHEMBL21940802 | 0.73 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10TSHR | |
| SCHEMBL21940505 | 0.72 | CHRM4 (0.35) | CHRM4MBOAT4NOS3NOS1NOS2 | |
| SCHEMBL21940483 | 0.72 | P4HTM (0.36) | P4HTM | |
| SCHEMBL25148366 | 0.66 | GRIN2D (0.32) | ALDH1A1HPGDKDM4EHSD17B10RECQL | |
| SCHEMBL25148409 | 0.66 | PDE10A (0.39) | ALDH1A1HPGDKDM4EHSD17B10RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |