Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940293 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1GAALMNAL3MBTL1 | |
| SCHEMBL21940582 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1GAALMNAL3MBTL1 | |
| SCHEMBL21940802 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1GAALMNAL3MBTL1 | |
| SCHEMBL21940294 | 0.83 | LRRK2 (0.44) | KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL21940791 | 0.83 | LRRK2 (0.44) | KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL21940290 | 0.75 | KDM4E (0.32) | KDM4EALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL21940286 | 0.73 | ALDH1A1 (0.42) | KDM4EALDH1A1GAALMNAL3MBTL1 | |
| SCHEMBL21940787 | 0.73 | CHRM4 (0.35) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL15831800 | 0.71 | HRH4 (0.66) | KDM4EALDH1A1GAALMNAL3MBTL1 | |
| SCHEMBL20606768 | 0.69 | LRRK2 (0.40) | KDM4EALDH1A1HSD17B10TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |