Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940540 | 0.77 | LRRK2 (0.40) | LRRK2IRAK4BRD4CREBBP | |
| SCHEMBL15730539 | 0.75 | FFAR1 (0.33) | — | |
| SCHEMBL21819819 | 0.74 | IRAK4 (0.38) | LRRK2IRAK4BRD4CREBBP | |
| SCHEMBL22900831 | 0.73 | USP30 (0.43) | IRAK4 | |
| SCHEMBL21940798 | 0.73 | — | — | |
| SCHEMBL15823377 | 0.71 | MAPK1 (0.30) | MAPK1 | |
| SCHEMBL2512007 | 0.71 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL17102316 | 0.71 | FFAR1 (0.43) | LRRK2IRAK4MAPK1 | |
| SCHEMBL18010602 | 0.71 | FFAR1 (0.43) | LRRK2IRAK4MAPK1 | |
| SCHEMBL1954029 | 0.71 | FFAR1 (0.43) | LRRK2IRAK4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |