Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18520809 | 0.85 | CDK2 (0.46) | ADORA2AADORA2BADORA1HPGDPDE2A | |
| SCHEMBL14644457 | 0.83 | HPRT1 (0.54) | ADORA2AADORA2BADORA1HPRT1ALDH1A1 | |
| SCHEMBL18822254 | 0.83 | HPRT1 (0.54) | ADORA2AADORA2BADORA1HPRT1ALDH1A1 | |
| SCHEMBL21943445 | 0.83 | HPGD (0.42) | HPGDPDE2AHPRT1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26199546 | 0.77 | PNP (0.47) | ADORA2AADORA1HPGDHPRT1ALDH1A1 | |
| SCHEMBL22571139 | 0.76 | KDM4E (0.47) | ADORA2AADORA2BADORA1HPRT1KDM4E | |
| SCHEMBL21625880 | 0.75 | ADORA2A (0.56) | ADORA2AADORA2BADORA1HPRT1PNP | |
| SCHEMBL3424722 | 0.74 | PDE1A (0.55) | ADORA2AHPGDHPRT1PNP | |
| SCHEMBL3427614 | 0.74 | CDK1 (0.47) | ADORA2AADORA1HPGDXDHPNP | |
| SCHEMBL30331956 | 0.74 | ADORA2A (0.50) | ADORA2AADORA2BADORA1CDK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200113924-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200113924-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | STING1, CGAS, MAVS | ADORA2A 900/4885ADORA2B 2261/4885ADORA1 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.