Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | YES1 | P07947 | 2/20 | 0.53 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.53 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.53 |
| ▸ | HACL2 | A1L0T0 | 1/20 | 0.53 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.53 |
| ▸ | GTPBP10 | A4D1E9 | 1/20 | 0.53 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.53 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.53 |
| ▸ | AGPS | O00116 | 1/20 | 0.53 |
| ▸ | ACOT7 | O00154 | 1/20 | 0.53 |
| ▸ | MYO1F | O00160 | 1/20 | 0.53 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.53 |
| ▸ | HAX1 | O00165 | 1/20 | 0.53 |
| ▸ | AIP | O00170 | 1/20 | 0.53 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.53 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.53 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.53 |
| ▸ | PSMD9 | O00233 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21943540 | 0.95 | BRAF (0.50) | BRAFLMNAYES1DDR2ESYT2 | |
| SCHEMBL21942995 | 0.89 | RAF1 (0.61) | BRAFLMNAYES1DDR2ESYT2 | |
| SCHEMBL21943537 | 0.89 | LMNA (0.51) | BRAFLMNAYES1DDR2ESYT2 | |
| SCHEMBL21942956 | 0.86 | BRAF (0.53) | BRAFLMNAYES1DDR2ESYT2 | |
| SCHEMBL21943354 | 0.85 | BRAF (0.49) | BRAFLMNAYES1RAF1SMN1; SMN2 | |
| SCHEMBL21942948 | 0.83 | KDR (0.49) | BRAFLMNAYES1ABL1SRC | |
| SCHEMBL21943629 | 0.82 | MAPK14 (0.65) | BRAFLMNAYES1DDR2ESYT2 | |
| SCHEMBL21943713 | 0.81 | RAF1 (0.58) | BRAFLMNAYES1DDR2ESYT2 | |
| SCHEMBL21943725 | 0.80 | ABL1 (0.78) | BRAFLMNAYES1DDR2ESYT2 | |
| SCHEMBL21943510 | 0.79 | RAF1 (0.51) | BRAFLMNAPDGFRBDDR1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | XIAMEN UNIVERSITY (CN) | 2022-05-03 | — | — | US | disclosed |
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | CYP4A11, CYP2D6, CYP3A43 | BRAF 95/4885LMNA 1474/4885YES1 722/4885 |
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | CYP4A11, CYP2D6, CYP3A43 | BRAF 95/4885LMNA 1474/4885YES1 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.