Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.58 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27334594 | 0.89 | TNNI3K (0.59) | EGFRTNNI3KERBB3MEN1KMT2A | |
| SCHEMBL690653 | 0.77 | EGFR (0.58) | EGFRTNNI3KABCG2ERBB2 | |
| SCHEMBL691187 | 0.75 | EGFR (0.57) | EGFRTNNI3KABCG2ERBB2 | |
| SCHEMBL2174864 | 0.75 | EGFR (0.71) | EGFRTNNI3KERBB3 | |
| SCHEMBL691533 | 0.75 | EGFR (0.57) | EGFRTNNI3KERBB3ABCG2NPC1 | |
| SCHEMBL690552 | 0.74 | EGFR (1.00) | EGFRTNNI3KERBB3KMT2ARAB9A | |
| SCHEMBL690934 | 0.73 | TNNI3K (0.54) | EGFRTNNI3KERBB3ABCG2ERBB2 | |
| SCHEMBL27330845 | 0.73 | TNNI3K (0.54) | EGFRTNNI3KERBB3ABCG2 | |
| SCHEMBL8798355 | 0.72 | EGFR (0.60) | EGFRTNNI3KERBB3MEN1KMT2A | |
| SCHEMBL27322789 | 0.72 | TNNI3K (0.63) | EGFRTNNI3KERBB3ABCG2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079343-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES | TECHNISCHE UNIVERSITAET WIEN (AT) | 2011-07-07 | — | — | WO | disclosed |