Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 4/20 | 0.50 |
| ▸ | BCR | P11274 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.49 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.49 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.49 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21943070 | 0.97 | MEN1 (0.53) | BRAFTEKPIKFYVEMEN1TSHR | |
| SCHEMBL21943450 | 0.92 | BRAF (0.51) | BRAFTEKMEN1KMT2APDGFRB | |
| SCHEMBL21943517 | 0.89 | TEK (0.57) | BRAFTEKPIKFYVEABL1BCR | |
| SCHEMBL21943069 | 0.89 | KDR (0.51) | BRAFTEKMEN1TSHRKMT2A | |
| SCHEMBL21943638 | 0.89 | BRAF (0.54) | BRAFTEKPIKFYVEABL1BCR | |
| SCHEMBL21943534 | 0.88 | KDR (0.58) | BRAFTEKPIKFYVEMEN1TSHR | |
| SCHEMBL21943013 | 0.87 | MAPK14 (0.54) | BRAFTEKPIKFYVEMEN1TSHR | |
| SCHEMBL21944047 | 0.84 | PIKFYVE (0.67) | BRAFTEKPIKFYVEMEN1TSHR | |
| SCHEMBL21975721 | 0.82 | MEN1 (0.49) | BRAFTEKPIKFYVEMEN1TSHR | |
| SCHEMBL22024869 | 0.82 | PIKFYVE (0.73) | BRAFTEKPIKFYVEABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | XIAMEN UNIVERSITY (CN) | 2022-05-03 | — | — | US | disclosed |
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | CYP4A11, CYP2D6, CYP3A43 | BRAF 95/4885TEK 2462/4885PIKFYVE 2706/4885 |
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | CYP4A11, CYP2D6, CYP3A43 | BRAF 95/4885TEK 2462/4885PIKFYVE 2706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.