Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | PIKFYVE | Q9Y2I7 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 7/20 | 0.48 |
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21943735 | 0.82 | BRAF (0.51) | MEN1KMT2ATSHRABL1BCR | |
| SCHEMBL21943070 | 0.79 | MEN1 (0.53) | MEN1KMT2ATSHRABL1BCR | |
| SCHEMBL21944047 | 0.79 | PIKFYVE (0.67) | MEN1KMT2ATSHRABL1BCR | |
| SCHEMBL12412290 | 0.77 | MEN1 (0.71) | MEN1KMT2ATSHRTEKBRAF | |
| SCHEMBL21943014 | 0.76 | PIKFYVE (0.65) | MEN1KMT2ATSHRABL1BCR | |
| SCHEMBL21943450 | 0.74 | BRAF (0.51) | MEN1KMT2ATEKBRAFPDGFRB | |
| SCHEMBL21944046 | 0.74 | BRAF (0.66) | MEN1KMT2ATSHRABL1BCR | |
| SCHEMBL21943325 | 0.74 | BRAF (0.52) | MEN1KMT2ATSHRABL1BCR | |
| SCHEMBL21943517 | 0.72 | TEK (0.57) | ABL1BCRPIKFYVETEKBRAF | |
| SCHEMBL21943069 | 0.71 | KDR (0.51) | MEN1KMT2ATSHRTEKBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |