Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 12/20 | 0.58 |
| ▸ | CDK9 | P50750 | 12/20 | 0.58 |
| ▸ | CDK4 | P11802 | 7/20 | 0.58 |
| ▸ | CCND1 | P24385 | 7/20 | 0.58 |
| ▸ | CDK2 | P24941 | 7/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.58 |
| ▸ | CDK1 | P06493 | 6/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.58 |
| ▸ | CDK3 | Q00526 | 6/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | CCNH | P51946 | 2/20 | 0.58 |
| ▸ | CCNC | P24863 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21946417 | 0.91 | CCNT1 (0.50) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL24174216 | 0.91 | CCNT1 (0.50) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL21946508 | 0.85 | CCNT1 (0.67) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL21946110 | 0.84 | CCNT1 (0.66) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL23992289 | 0.77 | CCNT1 (0.63) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL21946422 | 0.75 | CCNT1 (0.46) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL21946105 | 0.74 | CCNT1 (0.54) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL21946122 | 0.74 | CDK9 (1.00) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL21946104 | 0.73 | CDK9 (0.49) | CCNT1CDK9CDK4CCND1CDK2 | |
| SCHEMBL21877653 | 0.72 | CDK9 (0.48) | CCNT1CDK9CDK4CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2022-01-06 | — | — | US | disclosed |
| US-11155560-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | Kronos Bio, Inc. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20200131189-A1 | Compounds, Compositions, and Methods for Modulating CDK9 Activity | IGNOTA LABS LIMITED (GB) | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131189-A1 | Compounds, Compositions, and Methods for Modulating CDK9 Activity | CDK9, CDK19, CDK7 | CCNT1 55/4885CDK9 1/4885CDK4 11/4885 |
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | CDK9, CDK19, CDK7 | CCNT1 55/4885CDK9 1/4885CDK4 11/4885 |
| US-11155560-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | CDK9, CDK19, CDK7 | CCNT1 40/4885CDK9 1/4885CDK4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.