Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25700592 | 1.00 | TLR9 (0.38) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL26494307 | 0.92 | TLR9 (0.35) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL26494088 | 0.92 | TLR9 (0.35) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL25075140 | 0.92 | TLR9 (0.35) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL26494308 | 0.92 | TLR9 (0.35) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL25075122 | 0.92 | TLR9 (0.35) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL24832951 | 0.90 | KCNH2 (0.44) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL25075153 | 0.90 | ACHE (0.38) | TLR9TLR8TLR7CCR2KCNH2 | |
| SCHEMBL24233175 | 0.89 | ACHE (0.40) | TLR9TLR8TLR7ACHEHRH3 | |
| SCHEMBL26445224 | 0.89 | ACHE (0.36) | TLR9TLR8TLR7CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |